CLiX AI automates the interrogation and structure of patient’s narrative data to give CROs and Sponsors a distinct data-driven advantage at critical points throughout the clinical trial life cycle. With the CLiX accelerate solution it is possible to:
• Increase predictability and reduce risk during bid phase feasibility assessment
• Shorten study start-up time by speeding up subject recruitment
• Automate retrospective information sorting for more accurate risk evaluation and mitigation during post-market surveillance
Ok, that’s about it!
Products
WHITE PAPER – A PARADIGM SHIFT IN PATIENT RECRUITMENT FOR CLINICAL TRIALS
In the last two decades, technology has drastically changed how we conduct business and lead our personal lives. However, medicine and more specifically the business of clinical trials hasn’t kept up. Finding patients for clinical trials, or patient recruitment, is still conducted very much as it was 20 years ago with very little having changed.
It’s no surprise that enrolling a sufficient number of patients in trials remains a chief bottleneck in the drug development process, attributing to delays of up to six months or more in 45% of studies. Relying on manual chart review of patient records to identify eligible patients that match inclusion and exclusion criteria is burdensome, expensive and time intensive.
This White Paper takes an in-depth view of CNLP (Clinical Natural Language Processing) and demonstrates the power of automated pre-screening to find markedly more patients in less time.
CLiX for Clinical Trials
CLiX ENRICH for Clinical Trials
Through quick and efficient access to information-rich, unstructured, text-based patient data found in electronic medical records (EMRs), case report forms (CRFs), patient reported outcomes (PROs), clinical trial management systems (CTMS), electronic data capture (EDC) systems, trip reports and other clinical documentation systems, CLiX ENRICH for Clinical Trials increases the likelihood of success during particular stages of clinical trials -Feasibility, Subject Recruitment and Pharmacovigilance.
Videos
Protecting and Securing Patient Data
Paradigm Shift
Clinithink's CLiX ENRICH and CLiX AUTHOR
Steve Coca, MD from Ichan School of Medicine at Mt Sinai Presenting at Clinical Trials Summit
CLiX for Clinical Trials
Documents
A PARADIGM SHIFT IN PATIENT RECRUITMENT FOR CLINICAL TRIALS
EXECUTIVE SUMMARY
In the last two decades, technology has drastically changed how we conduct business and lead our personal lives. However, medicine and more specifically the business of clinical trials hasn’t kept up. Finding patients for clinical trials, or patient recruitment, is still conducted very much as it was 20 years ago with very little having changed.
It’s no surprise that enrolling a sufficient number of patients in trials remains a chief bottleneck in the drug development process, attributing to delays of up to six months or more in 45% of studies. Relying on manual chart review of patient records to identify eligible patients that match inclusion and exclusion criteria is burdensome, expensive and time intensive.
This White Paper takes an in-depth view of CNLP (Clinical Natural Language Processing) and demonstrates the power of automated pre-screening to find markedly more patients in less time.
CLINITHINK PARTNERS WITH MOUNT SINAI HEALTH SYSTEM TO TRANSFORM CLINICAL TRIALS RECRUITMENT
Following a successful evaluation of Clinithink, Ltd.’s CLiX ENRICH for Clinical Trials solution at the Icahn School of Medicine at Mount Sinai (ISMMS), Mount Sinai has signed an agreement with the company to deploy the solution across the organization to accelerate patient recruitment for clinical trials, as well as to support its personalized medicine initiatives.
CLiX ENRICH will help to streamline the patient pre-screening process at Mount Sinai by processing large volumes of progress notes and reports from electronic health records and flagging patients whose clinical documentation indicates they closely match a trial’s inclusion/exclusion criteria. The result is an ENRICHed List, a prioritized shortlist of highly eligible patients. This will allow investigators to be much quicker in selecting patients to approach for consent and screening. The solution removes the need for extensive manual chart reviews almost entirely, releasing valuable time traditionally spent by site investigators and coordinators on this laborious task.
Pharma Tech Outlook Selects Clinithink for Top 10 Clinical Data Management Solution Providers
Pharma Tech Outlook (www.pharmatechoutlook.com) has chosen Clinithink, (www.clinithink.com) for its Top 10 Clinical Data Management Solution Providers 2015. The positioning is based on evaluation of Clinithink’s capabilities in extracting clinical information from unstructured narrative to accelerate the patient identification in the recruitment stage of clinical trials.
ABMU PROSPECTIVE TRIAL IN PATIENT GROUP WITH TYPE 2 DIABETES MELLITUS AND OTHER SPECIFIC CONCOMITANT DISEASE CASE STUDY
An evaluation was conducted by the Joint Clinical Research Facility (JCRF), part of Abertawe Bro Morgannwg University (ABMU) Health Board in collaboration with Swansea University. Automated pre-screening using CLiX ENRICH, installed on one of Swansea University’s innovative National Research Data Appliances, was compared to current best practice in a currently enrolling multi-national, double blind, randomized, controlled clinical trial investigation of a medicinal product.
With recruitment having slowed to a standstill using current manual methods, CLiX ENRICH was used to provide a prioritized list of patients who were highly eligible for recruitment for the study.
By directing the investigators towards relevant patients in the ENRICHed List, enrollment numbers can be significantly increased in a markedly shorter timeline. CLiX ENRICH for Clinical Trials represents a breakthrough in recruitment efficiency where sponsors and research centers can achieve enrollment targets not only in time, but ahead of schedule with much less manual effort compared to current practice.
MOUNT SINAI PROSPECTIVE TRIAL IN PATIENT GROUP WITH DIABETIC NEPHROPATHY CASE STUDY
Investigators at the Icahn School of Medicine at Mount Sinai (ISMMS) worked with CLiX ENRICH to increase their recruitment potential. Having only enrolled one of seven eligible patients found over four months, investigators at ISMMS enhanced the recruitment process by introducing CLiX ENRICH.
Extrapolating the recruitment success rate for this trial, it is predicted that a further 13 patients will be enrolled. Compared with the one patient enrolled over four months without CLiX ENRICH, this represents a radical improvement in results for ISMMS and a paradigm shift in their recruitment process.
Mount Sinai Rare Disease Clinical Trial Case Study
As part of an evaluation conducted by the Icahn School of Medicine at Mount Sinai (ISMMS), automated recruitment with CLiX ENRICH was retrospectively compared to current best practice in a phase two, double blind, randomized control trial that had already been completed.
This project demonstrates the unique advantage offered by CLiX ENRICH in clinical trials where recruitment can be most challenging. With two weeks of focused resource use, CLiX queries can be authored and run against large volumes of data to provide an ENRICHed List of highly eligible patients for recruitment. By directing the investigators towards
relevant patients in the ENRICHed List, enrollment numbers can be significantly increased in a markedly shorter timeline.
Clinical Trials Sites discover how CLiX ENRICH for Clinical Trials can help you find 10x more patients, faster
A breakthrough in patient recruitment: save time & costs, find more eligible patients
FASTER & attract more trials.
10x the Pre-screen Patient Yield within ¼ of the Time. Meet your patient enrollment targets ahead of time and within budget
by unlocking the full potential of your Electronic Medical Records.
Sponsors discover how CLiX for Clinical Trials can help meet recruitment goals
A breakthrough in patient recruitment: reduce risks, save time and costs and get products to market faster. CLiX ENRICH for Clinical Trials helps Sponsors to meet enrollment deadlines and targets.
