Pharma Tech Outlook (www.pharmatechoutlook.com) has chosen Clinithink, (www.clinithink.com) for its Top 10 Clinical Data Management Solution Providers 2015. The positioning is based on evaluation of Clinithink’s capabilities in extracting clinical information from unstructured narrative to accelerate the patient identification in the recruitment stage of clinical trials.
An evaluation was conducted by the Joint Clinical Research Facility (JCRF), part of Abertawe Bro Morgannwg University (ABMU) Health Board in collaboration with Swansea University. Automated pre-screening using CLiX ENRICH, installed on one of Swansea University’s innovative National Research Data Appliances, was compared to current best practice in a currently enrolling multi-national, double blind, randomized, controlled clinical trial investigation of a medicinal product.
With recruitment having slowed to a standstill using current manual methods, CLiX ENRICH was used to provide a prioritized list of patients who were highly eligible for recruitment for the study.
By directing the investigators towards relevant patients in the ENRICHed List, enrollment numbers can be significantly increased in a markedly shorter timeline. CLiX ENRICH for Clinical Trials represents a breakthrough in recruitment efficiency where sponsors and research centers can achieve enrollment targets not only in time, but ahead of schedule with much less manual effort compared to current practice.
Investigators at the Icahn School of Medicine at Mount Sinai (ISMMS) worked with CLiX ENRICH to increase their recruitment potential. Having only enrolled one of seven eligible patients found over four months, investigators at ISMMS enhanced the recruitment process by introducing CLiX ENRICH.
Extrapolating the recruitment success rate for this trial, it is predicted that a further 13 patients will be enrolled. Compared with the one patient enrolled over four months without CLiX ENRICH, this represents a radical improvement in results for ISMMS and a paradigm shift in their recruitment process.
As part of an evaluation conducted by the Icahn School of Medicine at Mount Sinai (ISMMS), automated recruitment with CLiX ENRICH was retrospectively compared to current best practice in a phase two, double blind, randomized control trial that had already been completed.
This project demonstrates the unique advantage offered by CLiX ENRICH in clinical trials where recruitment can be most challenging. With two weeks of focused resource use, CLiX queries can be authored and run against large volumes of data to provide an ENRICHed List of highly eligible patients for recruitment. By directing the investigators towards
relevant patients in the ENRICHed List, enrollment numbers can be significantly increased in a markedly shorter timeline.